Publication date: 25th July 2016
Collective cell migration is ubiquitous among biological entities. The prevalent view of collective cell migration assumes a hierarchical leader-follower organization and belittles the contribution of follower cells in choosing or regulating the leaders. Furthermore, the biophysical link between formation and regulation of leader cells remains missing. Here, we uniquely report and analyse three distinct phases of collective cell migration and demonstrate how cellular-level shared decision-making process influence formation and regulation of leader cells in these phases. Investigating preparatory phase before the migration (Phase 0), we show that the selection of leader cells in the epithelial wound margin ultimately depends on the pre-migratory dynamics of the inner follower cells situated immediately behind the future leaders. This inherent dynamics override any preliminary bias imparted directly to the leading edge. Immediately after the initiation of migration (Phase 1), leaders show their phenotype and drive the movement. In this phase, pluricellular actin belt at the margin tightly regulate the propensity of leader cells. Non-leader marginal cells here reorient their focal adhesions towards the leaders thereby following the latter. Later during the migration (Phase 2), new leaders emerged from already existing outgrowths in order to minimize the tension at curvature-interface when the size of outgrowths increased. In the end, we show that in all phases, pharmacological perturbation in mechanical forces that modifies the force correlation lengths, invariably enforces a change in the length scale of guidance and therefore, the propensity of leader cells at the wound margin. Together, these findings provide a novel system-insight into formation and regulation of leader cells during collective cell migration.
nanoGe is a prestigious brand of successful science conferences that are developed along the year in different areas of the world since 2009. Our worldwide conferences cover cutting-edge materials topics like perovskite solar cells, photovoltaics, optoelectronics, solar fuel conversion, surface science, catalysis and two-dimensional materials, among many others.
nanoGe Fall Meeting (NFM) is a multiple symposia conference celebrated yearly and focused on a broad set of topics of advanced materials preparation, their fundamental properties, and their applications, in fields such as renewable energy, photovoltaics, lighting, semiconductor quantum dots, 2-D materials synthesis, charge carriers dynamics, microscopy and spectroscopy semiconductors fundamentals, etc.
This conference is a unique series of symposia focused on advanced materials preparation and fundamental properties and their applications, in fields such as renewable energy (photovoltaics, batteries), lighting, semiconductor quantum dots, 2-D materials synthesis and semiconductors fundamentals, bioimaging, etc.
International Conference on Hybrid and Organic Photovoltaics
International Conference on Hybrid and Organic Photovoltaics (HOPV) is celebrated yearly in May. The main topics are the development, function and modeling of materials and devices for hybrid and organic solar cells. The field is now dominated by perovskite solar cells but also other hybrid technologies, as organic solar cells, quantum dot solar cells, and dye-sensitized solar cells and their integration into devices for photoelectrochemical solar fuel production.
Asia-Pacific International Conference on Perovskite, Organic Photovoltaics and Optoelectronics
The main topics of the Asia-Pacific International Conference on Perovskite, Organic Photovoltaics and Optoelectronics (IPEROP) are discussed every year in Asia-Pacific for gathering the recent advances in the fields of material preparation, modeling and fabrication of perovskite and hybrid and organic materials. Photovoltaic devices are analyzed from fundamental physics and materials properties to a broad set of applications. The conference also covers the developments of perovskite optoelectronics, including light-emitting diodes, lasers, optical devices, nanophotonics, nonlinear optical properties, colloidal nanostructures, photophysics and light-matter coupling.
The International Conference on Perovskite Thin Film Photovoltaics Perovskite Photonics and Optoelectronics (NIPHO) is the best place to hear the latest developments in perovskite solar cells as well as on recent advances in the fields of perovskite light-emitting diodes, lasers, optical devices, nanophotonics, nonlinear optical properties, colloidal nanostructures, photophysics and light-matter coupling.